Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

The gut microbiota regulates T cell functions throughout the body. We hypothesized that intestinal bacteria impact the pathogenesis of multiple sclerosis (MS), an autoimmune disorder of the CNS and thus analyzed the microbiomes of 71 MS patients not undergoing treatment and 71 healthy controls. Alth...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cekanaviciute, Egle, Yoo, Bryan B., Runia, Tessel F., Debelius, Justine W., Singh, Sneha, Nelson, Charlotte A., Kanner, Rachel, Bencosme, Yadira, Lee, Yun Kyung, Hauser, Stephen L., Crabtree-Hartman, Elizabeth, Sand, Ilana Katz, Gacias, Mar, Zhu, Yunjiao, Casaccia, Patrizia, Cree, Bruce A. C., Knight, Rob, Mazmanian, Sarkis K., Baranzini, Sergio E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635915/
https://ncbi.nlm.nih.gov/pubmed/28893978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711235114
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