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Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor
Pilocarpine is a prototypical drug used to treat glaucoma and dry mouth and is classified as either a full or partial muscarinic agonist. Here, we report several unexpected results pertaining to its interaction with muscarinic M3 receptor (M3R). We found that pilocarpine was 1000 times less potent i...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Mol Pharmacol |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635516/ https://ncbi.nlm.nih.gov/pubmed/28893976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109678 |
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