Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells

We evaluated the impact of premature cell death of antigen-presenting cells (APCs) by Caspase-1- and RipK3-signaling pathways on CD8(+) T-cell priming during infection of mice with Salmonella typhimurium (ST). Our results indicate that Caspase1 and RipK3 synergize to rapidly eliminate infected APCs,...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Patel, Rajen, Kim, Kwangsin, Shutinoski, Bojan, Wachholz, Kristina, Krishnan, Lakshmi, Sad, Subash
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635216/
https://ncbi.nlm.nih.gov/pubmed/28686578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.112
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