Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

Amyloid plaques, consisting of deposited beta-amyloid (Aβ), are a neuropathological hallmark of Alzheimer’s Disease (AD). Cerebral vessels play a major role in AD, as Aβ is cleared from the brain by pathways involving the cerebrovasculature, most AD patients have cerebrovascular amyloid (cerebral am...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Robert, Jerome, Button, Emily B, Yuen, Brian, Gilmour, Megan, Kang, Kevin, Bahrabadi, Arvin, Stukas, Sophie, Zhao, Wenchen, Kulic, Iva, Wellington, Cheryl L
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2017
Предметы:
Human Biology and Medicine
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634784/
https://ncbi.nlm.nih.gov/pubmed/28994390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29595
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