ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

Activating transcription factor 4 (ATF4) is a critical mediator of metabolic and oxidative homeostasis and cell survival. ATF4 is elevated in response to diverse microenvironmental stresses, including starvation, ER stress damages and exposure to toxic factors. Here we show that ATF4 expression fost...

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Publicat a:Oncogene
Autors principals: Chen, D, Fan, Z, Rauh, M, Buchfelder, M, Eyupoglu, I Y, Savaskan, N
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633655/
https://ncbi.nlm.nih.gov/pubmed/28553953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.146
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