Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication

Peptide nucleic acids (PNAs) are potentially attractive antisense agents against hepatitis B virus (HBV), although poor cellular uptake limits their therapeutic application. In the duck HBV (DHBV) model, we evaluated different cell-penetrating peptides (CPPs) for delivery to hepatocytes of a PNA-tar...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Ndeboko, Bénédicte, Ramamurthy, Narayan, Lemamy, Guy Joseph, Jamard, Catherine, Nielsen, Peter E., Cova, Lucyna
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633256/
https://ncbi.nlm.nih.gov/pubmed/29246295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.09.003
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