P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy

Salivary gland inflammation is a hallmark of Sjögren's syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration of the salivary gland and loss of saliva secretion, predominantly in women. The P2X7 receptor (P2X7R) is an ATP-gated nonselective cation channel that indu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Khalafalla, Mahmoud G., Woods, Lucas T., Camden, Jean M., Khan, Aslam A., Limesand, Kirsten H., Petris, Michael J., Erb, Laurie, Weisman, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633125/
https://ncbi.nlm.nih.gov/pubmed/28798231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.790741
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