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A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle
Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy, one of the most prevalent heritable cardiovascular disorders. Studies on isolated cells and muscle...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5633120/ https://ncbi.nlm.nih.gov/pubmed/28808052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.776815 |
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