Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae

BACKGROUND: Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria. In this study, the mechanisms of action and the therapeutic efficacy of the hybrid peptides were examined. METHODS: TEM...

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Veröffentlicht in:PeerJ
Hauptverfasser: Jindal, Hassan Mahmood, Zandi, Keivan, Ong, Kien Chai, Velayuthan, Rukumani Devi, Rasid, Sara Maisha, Samudi Raju, Chandramathi, Sekaran, Shamala Devi
Format: Artigo
Sprache:Inglês
Veröffentlicht: PeerJ Inc. 2017
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632533/
https://ncbi.nlm.nih.gov/pubmed/29018620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.3887
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