Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

BACKGROUND: Focal cerebral ischemia induces distinct neuroinflammatory processes. We recently reported the extracellular phosphor-glyco-protein osteopontin (OPN) to directly affect primary microglia in vitro, promoting survival while shifting their inflammatory profile towards a more neutral phenoty...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Ladwig, Anne, Walter, Helene Luise, Hucklenbroich, Jörg, Willuweit, Antje, Langen, Karl-Josef, Fink, Gereon Rudolph, Rueger, Maria Adele, Schroeter, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632451/
https://ncbi.nlm.nih.gov/pubmed/29104378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7189421
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