Chemoselective fluorination and chemoinformatic analysis of griseofulvin: natural vs fluorinated fungal metabolites

Griseofulvin is a fungal metabolite and antifungal drug used for the treatment of dermatophytosis in both humans and animals. Recently, griseofulvin and its analogues have attracted renewed attention due to reports of their potential anticancer effects. In this study griseofulvin (1) and related ana...

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Udgivet i:Bioorg Med Chem
Main Authors: Paguigan, Noemi D., Al-Huniti, Mohammed, Raja, Huzefa A., Czarnecki, Austin, Burdette, Joanna E., González-Medina, Mariana, Medina-Franco, José L., Polyak, Stephen J., Pearce, Cedric J., Croatt, Mitchell P., Oberlies, Nicholas H.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632135/
https://ncbi.nlm.nih.gov/pubmed/28802670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.07.041
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