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Detection of Respiratory Pathogens in Parapneumonic Effusions by Hypothesis-free, Next-Generation Sequencing (NGS)

BACKGROUND: Species-specific polymerase chain reaction (PCR) testing of pleural fluid (PF) from children with parapneumonic effusion (PPE) has increased pathogen identification in pediatric PPE. However, a pathogen is not detected in 25–35% of cases. Hypothesis-free, next-generation sequencing (NGS)...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Ampofo, Krow, Pavia, Andrew, Blaschke, Anne J, Schlaberg, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631737/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx162.044
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