Cefepime-Zidebactam (WCK 5222) Activity Tested against Gram-negative Organisms Causing Bloodstream Infections Worldwide

BACKGROUND: Zidebactam (ZID), a bicyclo-acyl hydrazide, is a β-lactam enhancer with a dual mechanism of action involving selective and high binding affinity to Gram-negative (GN) PBP2 and β-lactamase inhibition. We evaluated the in vitro activity of cefepime (FEP) combined with ZID against GN organi...

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Bibliographic Details
Published in:Open Forum Infect Dis
Main Authors: Sader, Helio S, Castanheira, Mariana, Streit, Jennifer M, Duncan, Leonard R, Flamm, Robert K
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631344/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.922
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