Efavirenz-metabolizing polymorphisms, viral suppression, and depression in HIV-infected individuals initiating antiretroviral therapy in southwestern Uganda

BACKGROUND: Single-nucleotide polymorphisms (SNPs) in CYP2B6 have previously been associated with a 10-fold range in trough plasma efavirenz concentrations, but associations between these SNPs and efavirenz (EFV)-mediated viral suppression and tolerability remain unclear. METHODS: We evaluated three...

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Udgivet i:Open Forum Infect Dis
Main Authors: Chang, Jonathan, Lee, Sulggi, Hunt, Peter, Kroetz, Deanna, Siedner, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631238/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1087
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