Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ

The root of Polygonum multiflorum Thunb (PM) has been used in China to treat a variety of diseases, such as constipation, early graying of the hair and hyperlipemia. Recent evidence shows that PM causes idiosyncratic drug-induced liver injury (IDILI) in humans. In this study, we investigated the mol...

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Bibliographische Detailangaben
Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: Meng, Ya-kun, Li, Chun-yu, Li, Rui-yu, He, Lan-zhi, Cui, He-rong, Yin, Ping, Zhang, Cong-en, Li, Peng-yan, Sang, Xiu-xiu, Wang, Ya, Niu, Ming, Zhang, Ya-ming, Guo, Yu-ming, Sun, Rong, Wang, Jia-bo, Bai, Zhao-fang, Xiao, Xiao-he
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630669/
https://ncbi.nlm.nih.gov/pubmed/28649126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.32
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