Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

BACKGROUND: Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured plasma levels of syndecan-1, a marker for glycocalyx degradation. METHODS: The pre...

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Publicat a:Ann Intensive Care
Autors principals: Murphy, Laura S., Wickersham, Nancy, McNeil, J. Brennan, Shaver, Ciara M., May, Addison K., Bastarache, Julie A., Ware, Lorraine B.
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630541/
https://ncbi.nlm.nih.gov/pubmed/28986821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13613-017-0325-y
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