VRK1 promotes cisplatin resistance by up-regulating c-MYC via c-Jun activation and serves as a therapeutic target in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a common malignant disease characterized by poor prognosis. Chemoresistance remains a major cause of ESCC relapse. Vaccinia-related kinase 1 (VRK1) has previously been identified as a cancer-related gene. However, there is little research demonstrating an...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Liu, Zhen-Chuan, Cao, Kuo, Xiao, Zhao-Hua, Qiao, Liang, Wang, Xue-Qing, Shang, Bin, Jia, Yang, Wang, Zhou
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630360/
https://ncbi.nlm.nih.gov/pubmed/29029460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20020
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