Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints

In the era of genome-wide association studies (GWAS) and personalized medicine, predicting the impact of single nucleotide polymorphisms (SNPs) in regulatory elements is an important goal. Current approaches to determine the potential of regulatory SNPs depend on inadequate knowledge of cell-specifi...

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Bibliografski detalji
Izdano u:Genome Res
Glavni autori: Schwessinger, Ron, Suciu, Maria C., McGowan, Simon J., Telenius, Jelena, Taylor, Stephen, Higgs, Doug R., Hughes, Jim R.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2017
Teme:
Method
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630036/
https://ncbi.nlm.nih.gov/pubmed/28904015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.220202.117
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