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Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery

Messenger RNA (mRNA) represents a promising class of nucleic acid-based therapeutics. While numerous nanocarriers have been developed for mRNA delivery, the inherent labile nature of mRNA results in a very low transfection efficiency and poor expression of desired protein. Here we preassemble the mR...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Li, Jiahe, Wang, Wade, He, Yanpu, Li, Yingzhong, Yan, Emily Z., Zhang, Ketian, Irvine, Darrell J., Hammond, Paula T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629916/
https://ncbi.nlm.nih.gov/pubmed/28157292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.6b08447
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