RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC

RUNX3, runt-domain transcription factor, is a master regulator of gene expression in major developmental pathways. It acts as a tumor suppressor in many cancers but is oncogenic in certain tumors. We observed upregulation of RUNX3 mRNA and protein expression in nasal-type extranodal natural killer (...

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Vydáno v:Leukemia
Hlavní autoři: Selvarajan, V, Osato, M, Nah, G S S, Yan, J, Chung, T-H, Voon, D C-C, Ito, Y, Ham, M F, Salto-Tellez, M, Shimizu, N, Choo, S-N, Fan, S, Chng, W-J, Ng, S-B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629367/
https://ncbi.nlm.nih.gov/pubmed/28119527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.40
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