IL-10-Engineered Human CD4(+) Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism

T regulatory cells (Tregs) play a key role in modulating T cell responses. Clinical trials showed that Tregs modulate graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, their ability to mediate anti-leukemic activity (graft-versus-leukemia...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Locafaro, Grazia, Andolfi, Grazia, Russo, Fabio, Cesana, Luca, Spinelli, Antonello, Camisa, Barbara, Ciceri, Fabio, Lombardo, Angelo, Bondanza, Attilio, Roncarolo, Maria Grazia, Gregori, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628869/
https://ncbi.nlm.nih.gov/pubmed/28807569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.029
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