A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate worldwide, with limited treatment options. Glypican-3 (GPC3) is a glycosylphosphatidylinositol-anchored glycoprotein that is overexpressed in most HCC tissues but not in normal tissues. GPC3-targeting antibody therapy shows limit...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Wu, Qunfeng, Pi, Liya, Le Trinh, Thu, Zuo, Chaohui, Xia, Man, Jiao, Yu, Hou, Zhouhua, Jo, Sung, Puszyk, William, Pham, Kien, Nelson, David R., Robertson, Keith, Ostrov, David, Rameshwar, Pranela, Xia, Chang Qing, Liu, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628867/
https://ncbi.nlm.nih.gov/pubmed/28865999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.08.005
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