The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice

Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current therapies. Tyrosine kinase inhibitors have demonstrated therapeutic benefit i...

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Udgivet i:PLoS One
Main Authors: Reber, Laurent L., Starkl, Philipp, Balbino, Bianca, Sibilano, Riccardo, Gaudenzio, Nicolas, Rogalla, Stephan, Sensarn, Steven, Kang, Dongmin, Raghu, Harini, Sokolove, Jeremy, Robinson, William H., Contag, Christopher H., Tsai, Mindy, Galli, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628843/
https://ncbi.nlm.nih.gov/pubmed/28982129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185704
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