Treatment with Recombinant Human MG53 Protein Increases Membrane Integrity in a Mouse Model of Limb Girdle Muscular Dystrophy 2B

Limb girdle muscular dystrophy type 2B (LGMD2B) and other dysferlinopathies are degenerative muscle diseases that result from mutations in the dysferlin gene and have limited treatment options. The dysferlin protein has been linked to multiple cellular functions including a Ca(2+)-dependent membrane...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Gushchina, Liubov V., Bhattacharya, Sayak, McElhanon, Kevin E., Choi, Jin Hyuk, Manring, Heather, Beck, Eric X, Alloush, Jenna, Weisleder, Noah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628796/
https://ncbi.nlm.nih.gov/pubmed/28750735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.025
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