Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-cell Lymphoma

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous neoplasm and patients with relapsed/refractory disease exhibit resistance to standard therapies. We have previously demonstrated that the MUC1-C oncoprotein plays a critical role in protection from oxidative stress in CTCL cells. Targeting of MUC1-...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Jain, Salvia, Washington, Abigail, Leaf, Rebecca Karp, Bhargava, Parul, Clark, Rachael A, Kupper, Thomas S, Stroopinsky, Dina, Pyzer, Athalia, Cole, Leandra, Nahas, Myrna, Apel, Arie, Rosenblatt, Jacalyn, Arnason, Jon, Kufe, Donald, Avigan, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628140/
https://ncbi.nlm.nih.gov/pubmed/28729399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0060
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