Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research, and controversy since first proposed in 2003. Multiple meta-analyses...

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Publicado en:Mol Psychiatry
Main Authors: Culverhouse, Robert C., Saccone, Nancy L., Horton, Amy C., Ma, Yinjiao, Anstey, Kaarin J., Banaschewski, Tobias, Burmeister, Margit, Cohen-Woods, Sarah, Etain, Bruno, Fisher, Helen L., Goldman, Noreen, Guillaume, Sébastien, Horwood, John, Juhasz, Gabriella, Lester, Kathryn J., Mandelli, Laura, Middeldorp, Christel M., Olié, Emilie, Villafuerte, Sandra, Air, Tracy M., Araya, Ricardo, Bowes, Lucy, Burns, Richard, Byrne, Enda M., Coffey, Carolyn, Coventry, William L., Gawronski, Katerina, Glei, Dana, Hatzimanolis, Alex, Hottenga, Jouke-Jan, Jaussent, Isabelle, Jawahar, Catharine, Jennen-Steinmetz, Christine, Kramer, John R., Lajnef, Mohamed, Little, Keriann, Meyer zu Schwabedissen, Henriette, Nauck, Matthias, Nederhof, Esther, Petschner, Peter, Peyrot, Wouter J., Schwahn, Christian, Sinnamon, Grant, Stacey, David, Tian, Yan, Toben, Catherine, Van der Auwera, Sandra, Wainwright, Nick, Wang, Jen-Chyong, Willemsen, Gonneke, Anderson, Ian M., Arolt, Volker, Åslund, Cecilia, Bagdy, Gyorgy, Baune, Bernhard T., Bellivier, Frank, Boomsma, Dorret I., Courtet, Philippe, Dannlowski, Udo, de Geus, Eco J.C., Deakin, John F. W., Easteal, Simon, Eley, Thalia, Fergusson, David M., Goate, Alison M., Gonda, Xenia, Grabe, Hans J., Holzman, Claudia, Johnson, Eric O., Kennedy, Martin, Laucht, Manfred, Martin, Nicholas G., Munafò, Marcus, Nilsson, Kent W., Oldehinkel, Albertine J., Olsson, Craig, Ormel, Johan, Otte, Christian, Patton, George C., Penninx, Brenda W.J.H., Ritchie, Karen, Sarchiapone, Marco, Scheid, JM, Serretti, Alessandro, Smit, Johannes H., Stefanis, Nicholas C., Surtees, Paul G., Völzke, Henry, Weinstein, Maxine, Whooley, Mary, Nurnberger, John I., Breslau, Naomi, Bierut, Laura J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628077/
https://ncbi.nlm.nih.gov/pubmed/28373689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.44
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