Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies(1–5). This proposition, however, is complicated by spatial and temporal heterogeneity(6–14). Here we study genomic and expression profiles across 127 multi-sector or longitudinal...

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Udgivet i:Nat Genet
Main Authors: Lee, Jin-Ku, Wang, Jiguang, Sa, Jason K., Ladewig, Erik, Lee, Hae-Ock, Lee, In-Hee, Kang, Hyun Ju, Rosenbloom, Daniel S., Camara, Pablo G., Liu, Zhaoqi, van Nieuwenhuizen, Patrick, Jung, Sang Won, Choi, Seung Won, Kim, Junhyung, Chen, Andrew, Kim, Kyu-Tae, Shin, Sang, Seo, Yun Jee, Oh, Jin-Mi, Shin, Yong Jae, Park, Chul-Kee, Kong, Doo-Sik, Seol, Ho Jun, Blumberg, Andrew, Lee, Jung-Il, Iavarone, Antonio, Park, Woong-Yang, Rabadan, Raul, Nam, Do-Hyun
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627771/
https://ncbi.nlm.nih.gov/pubmed/28263318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3806
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