A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus

A therapy for dengue is still elusive. We describe the neutralizing and protective capacity of a dengue serotype-cross-reactive antibody isolated from the plasmablasts of a patient. Antibody SIgN-3C neutralized all four dengue virus serotypes at nano to picomolar concentrations and significantly dec...

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Udgivet i:NPJ Vaccines
Main Authors: Xu, Meihui, Zuest, Roland, Velumani, Sumathy, Tukijan, Farhana, Toh, Ying Xiu, Appanna, Ramapraba, Tan, Ern Yu, Cerny, Daniela, MacAry, Paul, Wang, Cheng-I, Fink, Katja
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627287/
https://ncbi.nlm.nih.gov/pubmed/29263863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-016-0003-3
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