Schisandra chinensis Stem Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity via Activation of the Nrf2 Pathway and Inhibition of the MAPKs and NF-κB Pathways

The beneficial value of the stems of Schisandra chinensis (SSC) in neurological diseases is unclear. We examined whether SSC aqueous extract (SSCE) alleviates striatal toxicity in a 3-nitropropionic acid (3-NPA)-induced mouse model of Huntington's disease (HD). SSCE (75, 150, or 300 mg/kg/day,...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Kim, Eun-Jeong, Jang, Minhee, Lee, Min Jung, Choi, Jong Hee, Lee, Sung Joong, Kim, Sun Kwang, Jang, Dae Sik, Cho, Ik-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627181/
https://ncbi.nlm.nih.gov/pubmed/29033839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00673
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