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Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8(+) T Cell Responses to Chronic Viral Infections and Cancer

In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called “immune checkpoints” by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immu...

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Detaylı Bibliyografya
Yayımlandı:Front Immunol
Asıl Yazarlar: Okoye, Isobel S., Houghton, Michael, Tyrrell, Lorne, Barakat, Khaled, Elahi, Shokrollah
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626929/
https://ncbi.nlm.nih.gov/pubmed/29033936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01215
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