Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells

Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have recently provided evidence that both drugs acting on...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Peruzzo, Roberta, Mattarei, Andrea, Romio, Matteo, Paradisi, Cristina, Zoratti, Mario, Szabò, Ildikò, Leanza, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626813/
https://ncbi.nlm.nih.gov/pubmed/29034212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00239
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