The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

Schwann cell dedifferentiation from a myelinating to a progenitor-like cell underlies the remarkable ability of peripheral nerves to regenerate following injury. However, the molecular identity of the differentiated and dedifferentiated states in vivo has been elusive. Here, we profiled Schwann cell...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Clements, Melanie P., Byrne, Elizabeth, Camarillo Guerrero, Luis F., Cattin, Anne-Laure, Zakka, Leila, Ashraf, Azhaar, Burden, Jemima J., Khadayate, Sanjay, Lloyd, Alison C., Marguerat, Samuel, Parrinello, Simona
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626803/
https://ncbi.nlm.nih.gov/pubmed/28957681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.09.008
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