Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer nanoparticles to show how physicochemical characteristics influence blood circulation and early distribution. For...

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Udgivet i:Nat Commun
Main Authors: Bertrand, Nicolas, Grenier, Philippe, Mahmoudi, Morteza, Lima, Eliana M., Appel, Eric A., Dormont, Flavio, Lim, Jong-Min, Karnik, Rohit, Langer, Robert, Farokhzad, Omid C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626760/
https://ncbi.nlm.nih.gov/pubmed/28974673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00600-w
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