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Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer nanoparticles to show how physicochemical characteristics influence blood circulation and early distribution. For...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bertrand, Nicolas, Grenier, Philippe, Mahmoudi, Morteza, Lima, Eliana M., Appel, Eric A., Dormont, Flavio, Lim, Jong-Min, Karnik, Rohit, Langer, Robert, Farokhzad, Omid C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626760/
https://ncbi.nlm.nih.gov/pubmed/28974673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00600-w
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