Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

Liver duct paucity is characteristic of children born with Alagille Syndrome (ALGS), a disease associated with JAGGED1 mutations. Here, we report that zebrafish embryos with compound homozygous mutations in two Notch ligand genes, jagged1b (jag1b) and jagged2b (jag2b) exhibit a complete loss of cano...

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Pubblicato in:Nat Commun
Autori principali: Zhang, Danhua, Gates, Keith P., Barske, Lindsey, Wang, Guangliang, Lancman, Joseph J., Zeng, Xin-Xin I., Groff, Megan, Wang, Kasper, Parsons, Michael J., Crump, J. Gage, Dong, P. Duc Si
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626745/
https://ncbi.nlm.nih.gov/pubmed/28974684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00666-6
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