Elevation of TP53 Autoantibody Prior to CA125 in Preclinical Invasive Epithelial Ovarian Cancer

PURPOSE: The TP53 tumor suppressor gene is mutated in >95% of high grade serous ovarian cancers. Detecting an autologous antibody response to TP53 might improve early detection. EXPERIMENTAL DESIGN: An immunoassay was developed to measure TP53 autoantibody in sera from 378 cases of invasive epith...

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Pubblicato in:Clin Cancer Res
Autori principali: Yang, Wei-Lei, Gentry-Maharaj, Aleksandra, Simmons, Archana, Ryan, Andy, Fourkala, Evangelia Ourania, Lu, Zhen, Baggerly, Keith A., Zhao, Yang, Lu, Karen H., Bowtell, David, Jacobs, Ian, Skates, Steven J., He, Wei-Wu, Menon, Usha, Bast, Robert C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626590/
https://ncbi.nlm.nih.gov/pubmed/28637689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0284
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