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Mitochondrial fission facilitates the selective mitophagy of protein aggregates
Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded protein response and PINK1–Parkin-mediated mitophagy to mitigate proteotoxicity. We explore how autophagy eliminates protein aggregates from within mitochondria and the role of mitochondrial fission in mitophag...
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| Pubblicato in: | J Cell Biol |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5626535/ https://ncbi.nlm.nih.gov/pubmed/28893839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612106 |
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