Mitochondrial fission facilitates the selective mitophagy of protein aggregates

Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded protein response and PINK1–Parkin-mediated mitophagy to mitigate proteotoxicity. We explore how autophagy eliminates protein aggregates from within mitochondria and the role of mitochondrial fission in mitophag...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Main Authors: Burman, Jonathon L., Pickles, Sarah, Wang, Chunxin, Sekine, Shiori, Vargas, Jose Norberto S., Zhang, Zhe, Youle, Alice M., Nezich, Catherine L., Wu, Xufeng, Hammer, John A., Youle, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626535/
https://ncbi.nlm.nih.gov/pubmed/28893839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612106
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