Reduced generation of lung tissue–resident memory T cells during infancy

Infants suffer disproportionately from respiratory infections and generate reduced vaccine responses compared with adults, although the underlying mechanisms remain unclear. In adult mice, lung-localized, tissue-resident memory T cells (TRMs) mediate optimal protection to respiratory pathogens, and...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Zens, Kyra D., Chen, Jun Kui, Guyer, Rebecca S., Wu, Felix L., Cvetkovski, Filip, Miron, Michelle, Farber, Donna L.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626403/
https://ncbi.nlm.nih.gov/pubmed/28855242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170521
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