Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation

Endoplasmic reticulum (ER) stress is commonly observed in intestinal epithelial cells (IECs) and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with IEC-specific deletion of X-box–binding protein 1 (Xbp1), an unfolded protein response–related transcription factor. In t...

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Vydáno v:J Exp Med
Hlavní autoři: Hosomi, Shuhei, Grootjans, Joep, Tschurtschenthaler, Markus, Krupka, Niklas, Matute, Juan D., Flak, Magdalena B., Martinez-Naves, Eduardo, Gomez del Moral, Manuel, Glickman, Jonathan N., Ohira, Mizuki, Lanier, Lewis L., Kaser, Arthur, Blumberg, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626394/
https://ncbi.nlm.nih.gov/pubmed/28747426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162041
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