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Biomarkers for Response of Melanoma Patients to Immune Checkpoint Inhibitors: A Systematic Review

BACKGROUND: Immune checkpoint inhibitors (ICIs), targeting CTLA-4 or PD-1 molecules, have shown impressive therapeutic results. However, only 20–40% of advanced melanoma patients have durable responses to ICI, and these positive effects must be balanced against severe off-target immune toxicity and...

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Bibliografiske detaljer
Udgivet i:Front Oncol
Main Authors: Jessurun, Charissa A. C., Vos, Julien A. M., Limpens, Jacqueline, Luiten, Rosalie M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625582/
https://ncbi.nlm.nih.gov/pubmed/29034210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00233
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