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Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ

The pathogenesis of human T cell leukemia virus type 1 (HTLV-1) is strongly linked to the viral regulatory proteins Tax1 and HBZ, whose opposing functions contribute to the clinical outcome of infection. Type I interferons alpha and beta (IFN-α and IFN-β) are key cytokines involved in innate immunit...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Narulla, Manraj Singh, Alsairi, Ahlam, Charmier, Lucie, Noonan, Stephen, Conroy, David, Hall, William W., Sheehy, Noreen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625481/
https://ncbi.nlm.nih.gov/pubmed/28768861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00853-17
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