Inhibition of HDAC enhances STAT acetylation, blocks NF-κB, and suppresses the renal inflammation and fibrosis in Npr1 haplotype male mice

Guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) plays a critical role in the regulation of blood pressure and fluid volume homeostasis. Mice lacking functional Npr1 (coding for GC-A/NPRA) exhibit hypertension and congestive heart failure. However, the underlying mechanisms remain largely...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Kumar, Prerna, Gogulamudi, Venkateswara R., Periasamy, Ramu, Raghavaraju, Giri, Subramanian, Umadevi, Pandey, Kailash N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625105/
https://ncbi.nlm.nih.gov/pubmed/28566502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00166.2017
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