Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight

5-Oxoproline (OP) is well-known as an enzymatic intermediate in the eukaryotic γ-glutamyl cycle, but it is also an unavoidable damage product formed spontaneously from glutamine and other sources. Eukaryotes metabolize OP via an ATP-dependent 5-oxoprolinase; most prokaryotes lack homologs of this en...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Niehaus, Thomas D., Elbadawi-Sidhu, Mona, de Crécy-Lagard, Valérie, Fiehn, Oliver, Hanson, Andrew D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Metabolism
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625064/
https://ncbi.nlm.nih.gov/pubmed/28830929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805028
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