Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma

Most hepatocellular carcinomas (HCC) develop as a result of chronic liver inflammation. We have shown that the oncoprotein gankyrin is critical for inflammation‐induced tumorigenesis in the colon. Although the in vitro function of gankyrin is well known, its role in vivo remains to be elucidated. We...

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Bibliografski detalji
Izdano u:Cancer Sci
Glavni autori: Sakurai, Toshiharu, Yada, Norihisa, Hagiwara, Satoru, Arizumi, Tadaaki, Minaga, Kosuke, Kamata, Ken, Takenaka, Mamoru, Minami, Yasunori, Watanabe, Tomohiro, Nishida, Naoshi, Kudo, Masatoshi
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623735/
https://ncbi.nlm.nih.gov/pubmed/28777492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13341
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