Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma

Most hepatocellular carcinomas (HCC) develop as a result of chronic liver inflammation. We have shown that the oncoprotein gankyrin is critical for inflammation‐induced tumorigenesis in the colon. Although the in vitro function of gankyrin is well known, its role in vivo remains to be elucidated. We...

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Bibliografiske detaljer
Udgivet i:Cancer Sci
Main Authors: Sakurai, Toshiharu, Yada, Norihisa, Hagiwara, Satoru, Arizumi, Tadaaki, Minaga, Kosuke, Kamata, Ken, Takenaka, Mamoru, Minami, Yasunori, Watanabe, Tomohiro, Nishida, Naoshi, Kudo, Masatoshi
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623735/
https://ncbi.nlm.nih.gov/pubmed/28777492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13341
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