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Recombinant Factor VIIa addition to hemophilic blood perfused over collagen/tissue factor can sufficiently bypass the Factor IXa/VIIIa defect to rescue fibrin generation
INTRODUCTION: Factor VIII or FIX-deficient hemophilic patients display deficits in platelet and fibrin deposition under flow detectable in microfluidics. Compared to fibrin generation, decreased platelet deposition in hemophilic blood flow is more easily rescued with recombinant factor VIIa (rFVIIa)...
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| Publicado no: | Haemophilia |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5623167/ https://ncbi.nlm.nih.gov/pubmed/28475272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hae.13259 |
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