Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction

Stimulator of interferon genes (STING) is a critical signaling molecule in the innate immune response against DNA viruses by either directly sensing intracellular DNA or functioning as an adaptor molecule to activate the type I interferon (IFN) signaling pathway. We determined the functional interac...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Kim, Jung-Eun, Kim, Young-Eui, Stinski, Mark F., Ahn, Jin-Hyun, Song, Yoon-Jae
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622937/
https://ncbi.nlm.nih.gov/pubmed/29018427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.01854
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