Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

BACKGROUND: The Connectivity Map (CMAP) database, an important public data source for drug repositioning, archives gene expression profiles from cancer cell lines treated with and without bioactive small molecules. However, there are only one or two technical replicates for each cell line under one...

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Detalles Bibliográficos
Publicado en:J Transl Med
Main Authors: He, Jun, Yan, Haidan, Cai, Hao, Li, Xiangyu, Guan, Qingzhou, Zheng, Weicheng, Chen, Rou, Liu, Huaping, Song, Kai, Guo, Zheng, Wang, Xianlong
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622488/
https://ncbi.nlm.nih.gov/pubmed/28962576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1302-9
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