Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells

Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8(+) T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms und...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Battisti, Federico, Napoletano, Chiara, Rahimi Koshkaki, Hassan, Belleudi, Francesca, Zizzari, Ilaria Grazia, Ruscito, Ilary, Palchetti, Sara, Bellati, Filippo, Benedetti Panici, Pierluigi, Torrisi, Maria Rosaria, Caracciolo, Giulio, Altieri, Fabio, Nuti, Marianna, Rughetti, Aurelia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622295/
https://ncbi.nlm.nih.gov/pubmed/28993771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01179
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