Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome

Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-rele...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kano, Michiko, Muratsubaki, Tomohiko, Van Oudenhove, Lukas, Morishita, Joe, Yoshizawa, Makoto, Kohno, Keiji, Yagihashi, Mao, Tanaka, Yukari, Mugikura, Shunji, Dupont, Patrick, Ly, Huynh Giao, Takase, Kei, Kanazawa, Motoyori, Fukudo, Shin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622133/
https://ncbi.nlm.nih.gov/pubmed/28963545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09635-x
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