Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor

Placental growth factor (PlGF), abundantly produced from trophoblasts is involved in placental angiogenesis. The regulatory mechanism of its expression is poorly understood. Hypoxia inducible factors (HIFs) are centrally involved in the modulation of cellular function in response to low oxygen condi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fujii, Tatsuya, Nagamatsu, Takeshi, Morita, Kazuki, Schust, Danny J., Iriyama, Takayuki, Komatsu, Atsushi, Osuga, Yutaka, Fujii, Tomoyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622029/
https://ncbi.nlm.nih.gov/pubmed/28963486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12685-w
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