Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis

To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)–MN). We observed micron-sc...

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Publicado en:Pharmaceutics
Autores principales: Katsumi, Hidemasa, Tanaka, Yutaro, Hitomi, Kaori, Liu, Shu, Quan, Ying-shu, Kamiyama, Fumio, Sakane, Toshiyasu, Yamamoto, Akira
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620570/
https://ncbi.nlm.nih.gov/pubmed/28817072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics9030029
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